A commercial for a new medication states that the medication can alleviate depression. "since depression is a chemical imbalance, new venlafaxine's extended release can help with mood, sleep, arousal, and alertness by working on the two key neurotransmitters involved in depression." these two neurotransmitters are

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The answer to this question is Serotonin, norepinephrine
Serotonin in our brain is responsible to influence our behavior and social response, Norepinephrine on the other hand, played a really huge role in out sympathetic nervous system which will affect our decision during fight-or-flight situations